JAMA Ophthalmology

Filamentous RPE Hyperplasia in Combined Hamartoma of the Retina and RPE

This case report describes a diagnosis of combined hamartoma of the retina and retinal pigment epithelium (RPE) with filamentous RPE hyperplasia in a female child with a history of amblyopia, myopia, and exotropia of the affected eye.

Fluorescein Angiography of Floating Retinal Veins

This case report describes a diagnosis of floating retinal veins in a patient aged 4 years with a history of stage 2 familial exudative vitreoretinopathy.

Vitreopapillary Traction in Stickler Type IV COL9A1

This case report describes a woman aged 43 years with Stickler syndrome and bilateral vitreopapillary traction who presented with shadows and ghosting of vision in both eyes.

Acute Corneal Edema in a Middle-Aged Patient

A middle-aged patient who had bilateral penetrating keratoplasty 20 years ago for keratoconus presented with pain and blurriness of the right eye for 2 days. Despite prompt corticosteroid therapy, they had no vision improvement and reported occasional pain. What would…

Interventions for Proliferative Vitreoretinopathy

Clinical Question  What is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy? Bottom Line  There is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.

Interventions for Dry Eye – An Overview of Systematic Reviews

Importance  Dry eye is a common ocular disease that can have substantial morbidity. Systematic reviews provide evidence for dry eye interventions and can be useful for patients, clinicians, and clinical guideline developers. Overviews of reviews use explicit and systematic methods to…

Human Whole-Eye Donation for Research Optimizing Clinical Trial Informed Consent

Importance  Posthumous whole-eye (globe) donations for research lack a mechanism that reinvolves the existing ophthalmic research team of the donor unless there is a preplanned donor directive. Disconnection between the deceased and their research team equates to lost opportunities for the…

Morning Glory Syndrome in a Newborn Aged 2 Weeks

This case report describes a diagnosis of morning glory syndrome in a 2-week-old infant who presented with divergent strabismus, cleft lip, and hypertelorism.