JAMA Oncology

An Atypical Rash on the Chest

A 71-year-old man presented with a rapidly progressing rash and swelling of the left side of the chest wall. What is your diagnosis?

Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer – A Review

Importance  Amplification of ERBB2 (formerly referred to as HER2) is present in nearly 3% of patients with metastatic colorectal cancer overall and 5% of patients with KRAS and NRAS wild-type tumors. Despite the availability of several ERBB2-targeted therapeutic options for patients with ERBB2-positive breast and gastric/gastroesophageal tumors, to…

Asymptomatic Cutaneous Plaques on the Scalp and Face in an Older Adult Woman

A 79-year-old female patient presented with a 2-year history of asymptomatic erythematous-infiltrated patches and plaques on the right side of her scalp and face, which gradually enlarged and coalesced into large plaques and nodules. What is your diagnosis?

Antibody Response in Immunocompromised Patients With Hematologic Cancers Who Received a 3-Dose mRNA-1273 Vaccination Schedule for COVID-19

Importance  It has become common practice to offer immunocompromised patients with hematologic cancers a third COVID-19 vaccination dose, but data substantiating this are scarce. Objective  To assess whether a third mRNA-1273 vaccination is associated with increased neutralizing antibody concentrations in immunocompromised patients…